Frauke BAYMANN will defend her thesis on Thursday 31 March at 2pm in the P. DESNUELLE amphitheatre on the Joseph Aiguier campus.

Jury

  • Dr. Catherine Berthomieu, CEA Cadarache (Chair)
  • Prof. Roberta Croce, University of Amsterdam (Rapporteur)
  • Dr. Geneviève Blondin, CEA Grenoble (Rapporteur)
  • Prof. Petra Hellwig, University of Strasbourg (Rapporteur)
  • Dr. Barbara Schoepp-Cothenet, CNRS Marseille (Tutor)
  • Dr. Florence Lederer, University of Paris Sud
  • Dr. Amandine Marechal, UCL London

Abstract :

25 years of work on the same enzyme, and plans for the 15 years to come – this may sound like an obsession. What is so special about the Rieske/cytb complex to keep me busy for decades? 

Rieske/cytb complexes are part of most bioenergetics reaction chains. They accept electrons from the quinone pool and transfer them to a terminal oxidase. Whatever quinone reductase and terminal oxidase there are, you will nearly always find the Rieske/cytb as the third party and this ever since the common ancestor of all living beings. 

Working with the Rieske/cytb complex is therefore like travelling with a faithful companion: it takes you to a stroll across biodiversity, makes you meet many different metabolisms and allows a time travel back to the Last Universal Common Ancestor. 

I sampled members of the Rieske/cytb enzyme family on this journey, traced down their common threats to conclude on the essentials empowering function while marveling at their diversity, thereby exploring a wide range of adaptations and interactions with their metabolic environment.  Enough to stay hooked!

Monday 2nd,
May 2022 02:00

IMM

Published on 24/03/2022

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